Search results for "Shab Potassium Channels"

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The Retinal Clock Drives the Expression ofKcnv2, a Channel Essential for Visual Function and Cone Survival

2012

PURPOSE The gene Kcnv2 codes for the voltage-gated potassium channel subunit Kv8.2, which can coassemble with Kv2.1 subfamily members to constitute functional voltage-gated potassium channels. Mutations in the Kcnv2 gene result in a retinal disorder designated "cone dystrophy with supernormal rod response (CDSRR)," revealing that Kcnv2 is essential for visual processing and cone survival. The aim of this study was to determine whether expression of Kcnv2 and Kv2.1 is under circadian regulation and may thus contribute to the clock-driven adjustment of photoreceptor function. METHODS Expression of the genes was recorded in preparations of the whole retina and microdissected retinal neurons by…

MaleRetinal Disordergenetic structuresCell SurvivalCone dystrophy with supernormal rod responseBlotting WesternBiologyReal-Time Polymerase Chain ReactionRetinaRats Sprague-Dawleychemistry.chemical_compoundShab Potassium ChannelsmedicineTranscriptional regulationAnimalsImmunoprecipitationRNA MessengerGeneVision OcularRetinaRetinalAnatomyAdaptation PhysiologicalPotassium channelCircadian RhythmRatsCell biologymedicine.anatomical_structureReal-time polymerase chain reactionGene Expression RegulationchemistryPotassium Channels Voltage-GatedRetinal Cone Photoreceptor CellsFemalesense organsInvestigative Opthalmology & Visual Science

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